welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, October 12, 2012

those rats

Walk to End Alzheimers
we are walking in the bell county/temple 
walk to end alzheimers on saturday november 3 2012

you can walk free but a donation to and or joining
my organicgreendoctor team is appreciated

join us there


there are rats and mice that have been genetically programmed
to develop alzheimers
all of them get the disease
so new treatments and tests are tried on these varmints first before
they do human studies

many times though what works in them wont work in humans

one study put a cell phone in the cage with the rats for a certain
amount of time each day and followed them for a period of months
those with the cell phone in the cage had a lower incidence of
must have been a smartphone
another reason its called that

in korea a researcher infused stem cells that ended up in the brain
of these alzheimers destined mice
the mice got better on their cognitive skills
didnt know they could think
and there was evidence that there was improvement in the
pathology of the brain

the stem cells were from adipose tissue
easily obtained now in the united states with our over abundant
supply of adipose

wonder what would happen if this was given to humans

bexarotene is a chemotherapy agent that is approved by the fda to be
used against certain skin cancers
so its available now and experience with it exists

in an experiment with those same old rats
they take a beating dont they
when these alzheimers rats received the bexarotene
there was reversal of the pathological changes behavior changes
and memory deficits caused by the onset of alzheimers

it apparently works by increasing the apoe gene expression which
increases how much beta amyloid is cleared from the brain
(beta amyloid is that sticky stuff that may be the cause or end
result of the alzheimers disease process)

so this could be a treatment that may be effective in people like
me who carry the sucky apoe 4 genotype for alzheimers
(i carry the double allele of this gene)

researchers are looking at starting its use in humans soon to see if
the results they got in mice will be the same  in humans

hey take me take me take me
i dont have skin cancer but i do have sunspots on my face and
ill gladly withstand the side effects of bexarotene

it cant be worse than whats coming down the pike for me if i do
have alzheimers

sometimes things are just that simple
we already got the drug
lets see if it works

i got an idea why dont they look at those patients who have already taken
the drug bexarotene for their skin cancer and see if some of them turned
out to have alzheimers later on and see if it helped them

i say game on

the organicgreen doctor

No comments:

Post a Comment