welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Tuesday, November 26, 2013

what if

for those of us who follow the alzheimers research
there are two things that we know about and are anxiously awaiting
the results

a4 study
colombian study

in both these studies
people in the a4 study who have
positive beta amyloid in the brain on scans called
amyvid pet scans and abnormal levels of beta amyloid and
tau levels in the spinal fluid
and in the case of the colombian study
family members who carry the gene for alzheimers that
means you will get the disease will also have these
two tests done

no one in either group have any symptoms yet

both studies will have regular amyvid pet scans and spinal
fluid analysis for the beta amyloid and tau
both imply if positive that the patient will get or will have
alzheimers disease


the study subjects will also be given one of the new alzheimers vaccines
which will induce or produce antibodies against
the beta amyloid and remove it from the brain

over time we will know if giving this vaccine early on
will prevent the development of alzheimers disease
which it will if the beta amyloid theory is correct

how does this affect me
the ogd

this last week i had my regular yearly visit with my neurologist
for follow up for
my early mild cognitive impairment amnestic type
that may turn out to be from alzheimers disease
diagnosed almost 3 years ago

i have been stable over this period of time except for some
mild problems with short term memory that only i notice

i presently take aricept (donepezil) 10 mg for the possibility
of having alzheimers dsease
its used when the diagnosis is first made or in my case
strongly suspected

i take care of my health
especially my blood pressure and cholesterol
2 of the 3 most important to control to prevent or slow down
alzheimers diesease
the third is diabetes which i dont have
more about this later

what i am looking for in research studies now

im in the alzheimers disease neuroimaging initiative now
its not a treatment study but its the most important one ever done
on alzheimers disease
the information from this study has provided the basis for the
a4 and colombian studies

i want to get treatment now while im so early no one notices anything
these two studies would be what im looking for

the colombian study is restricted to family members in colombia
that carry that awful gene which means they will get it
i know that i dont have that gene since ive been tested

the a4 does not
if i qualify i will get the beta amyloid scan amyvid and yes have
to get that dang spinal tap again and again
but i might receive one of those new alzheimers vaccine
that if it works would slow down the process at least while
i was on the study
unless of course i would get put in the control group
which i dont want to be in

if i dont qualify for that one
i will get in a nasal insulin study for 6 months
the nasal insulin increase the glucose into the nerve cells
in the brain where alzheimers starts as the insulin travels up the
olfactory nerve the smeller nerve i call it
which may slow down but wont prevent the disease
this may be my fall back study

then in 2014 or 2015 there is a study that will start in arizona

where those who carry the apoe4/apoe4 double gene like i have
which increases your chance of getting alzheimers disease significantly
will be given either a new research drug or one of the new
alzheimers vaccines
will be followed over a period of time monitoring the
beta amyloid scans and levels and the tau levels to see if they decrease
and to see if it prevents the development of the disease

the budget cuts and sequester had shut this study down
but the nih scrapped up funds to get it going

i am on the contact list for that study when it starts
i will do it if i qualify
please on please dont put me in the control group

the organicgreen doctor

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