welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, February 14, 2014

trim, alzheimers answers maybe

yesterday i blogged on trimming time
here is a link to the blog from central texas gardener for more
on pruning and trimming with links
on what to trim and when

the theory of alzheimers is that beta amyloid accumulates in
the brain
this accumulation is what causes the spiraling destruction
of alzheimers disease

if you can stop the beta amyloid production and stop its accumulation
and remove it if its accumulated
maybe just maybe you can prevent or treat alzheimers

if you wait too long and allow destruction to occur then it may be too late

you know me
at least some of you do
i seem a normal healthy person
few can detect i have a problem
heck yesterday i had to convince a social security worker that
i could handle my own financial affairs
i did
my wife she was happy about that

i carry the double gene apoe4 and have short term memory loss
my parents and younger brother had alzheimers disease
so the odds are i have it also
i am on aricept (donepezil) for this possibility

i may be too late for this treatment since if i have alzheimers disease
as i may be too far along this path

my wife she and i went to the alzheimers research center at ut southwestern
last weekend to a brunch where they discussed research that was
being done

three new studies that are being started nationally will be done there
as one of the studies sites

the a4 study
basically they will be doing neuropsych tests on folks who have no
do the beta amyloid pet scans called amyvid
do spinal taps for beta amyloid and tau proteins those two proteins that
become abnormal in the spinal fluid in alzheimers disease
all three of these tests become abnormal before the disease is noticed

then those who are positive will be placed in a study using one of the
new alzheimers vaccines called solanezumab
the vaccine uses antibodies that attach itself to the beta amyloid and
removes it from the brain
thus preventing the development of alzheimers disease
thats the theory and hope

the study subjects will be placed either in the antibody group
or a placebo
no placebo for me
there is a 50% chance that i would be in a treatment group
i already know my beta amyloid levels in my spinal fluid are abnormal

my problem is that the study requires you be 65 and im not quite there yet
dang it

if you are kin to be and are 65 or older you are a good candidate for this
or if you are worried or at high risk
they need people to volunteer for the study
the center serves folks from oklahoma arkansas louisiana and texas

you have to have intial scans neuropsych tests to see if you are at risk
if accepted
you will get monthly infusions of the new alzheimers vaccine or get placebo
if you are in the vaccine group
if this vaccine works
if you are
getting alzheimers you will not get alzheimers disease or the progression
will be slowed
the study is programmed for i think two years
if it works this drug may be on the market in 4 years

i personally want to be in this study bad but  im one year too young

but there are other studies coming up using this same new vaccine
but not until next year

time is of the essence

you may contact the alzheimers research center at ut southwestern at
ask for kathy koch
go to www.alz.org to find a study in your area

there is another study starting up at the alzheimers research center
using the same vaccine in folks who have early alzheimers disease
my problem on that one is that i am not far enough along in the
disease process to qualify

then another study they will be doing is called the sniff study
using nasal insulin
sniff it up the right nostril it goes to the right brain
sniff it up the left nostril it goes to the left brain
it manages to go right to the smeller nerve the olfactory nerve
and travel bypassing that blood brain barrier to get directly to
the hippocampas where alzheimers disease starts

it raises the insulin level there and forces more glucose into the
brain cells
slowing down the disease and maybe preventing it

my spinal tap guy
the one i jokely accuse of rupturing my disk last time he did mine
is the head study person for the study
no thats not what caused my ruptured disk
that was years in the making

my spinal taps i know they sound bad didnt hurt
actually i didnt feel anything
but i did when they drew my blood

so these three studies are available in this area
you again can call the alzheimers research center at
ask for kathy koch
check the clinical trials section of www.alz.org
for your local centers at
the alzheimers association website

we need you help
your kids nieces nephews and the future generations
need your help

we wont know if this works unless you and i volunteer
please help us

saying i dont want to know may not be a valid excuse anymore
maybe in the future you will want to know so you can be treated

when you call them tell them i sent you
dr nash
organicgreen doctor

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