welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, December 16, 2016

alzheimers news-todays the day

two weeks ago the alzheimers vaccine study on solanezumab came out
the results werent promising
however there was a 15% improvement noted in those folks
with mild alzheimers disease
this vaccine an antibody against beta amyloid doesnt go after the
plaques that form from beta amyloid in the brain
my drug does though
it appears that for this stuff or any new alzheimers drug to be
it has to be used in folks like me with minimal disease
those folks like some of you that have prodromal alzheimers
you just dont have symptoms yet but the disease process is
going on and has been for several years

once you get full blown alzheimers disease it may be too late
for a treatment

the solanezumab study called a4 results will be out in a few years
its on prodromal folks

if any of  you saw the 60 minutes show on alzheimers disease
that was a story of using one of these drugs called crenezumab
in a large extended family of folks in colombia who will get
alzheimers since they carry the dominant alzheimers gene

this one works more like the one thats being used in the study
i have been trying to get in

todays that day
i passed hurtle number one
i got past the nurse screener
i have been accepted to enter the prescreening part of their study

this one i think is the most promising of all the drugs so far
Aducanumab, a new drug, caused a dose-dependent reduction in amyloid plaques, a key feature of Alzheimer's disease. Photo by Sevigny et al., Nature, 2016
npr article on aducanumab

this last week at a large alzheimers conference in san diego
the data from its phase 1 study was discussed

in folks with minimal symptoms
like me
not only did the beta amyloid get removed from the brain plaques
and the cs fluid around the brain
folks memory stayed the same or got better
the placebo folks who didnt get the drug
their memories deteriorated

there is a memory test commonly used in doctors offices
called the mmse
you get a score of 0-30
placebo folks deteriorated almost 2 points
treated folks didnt change or declined much slower
based on which dose of the drug they got

so for me i would accept no change or mild decline

the alternative to doing nothing
thats not good
its real bad

so today i get started on several more hurtles

my wife she and i make the trip to dallas
to the alzheimers center at ut southwestern
to start my journey
one i have been hoping for for 6 years now

it starts with an interview with the research nurse
asking me and my wife she lots of questions
all 1000+ of us in this national study go through the same thing

this visit or maybe the next visit if i pass this one
i get a lot of blood drawn
240 ml or 8 oz

i undergo that torture test
called neuropsych testing
which includes the mmse and other memory tests that the study is using

i undergo a neurological history and examination by the
studys primary investigator
a neurologist

this data is sent off to biogen the maker of the aducanumab drug
to decide if i go further in the study

if declined i will have an amyvid pet scan done privately
will move on with my life
looking for a another promising treatment
the clocks ticking on me

if i am accepted
i move to a spinal tap for beta amyloid and the tau protein
genetic testing

if i am accepted based on these results
then i get the final test
the amyvid or amyloid pet scan
it will tell if i have the amyloid accumulated in the brain
if positive
im in
that means i know i have alzheimers disease for sure
well as sure as one can know without an autopsy of the brain

i will start infusions monthly
of a placebo ie water
the real deal

i have a 67% chance of getting the real deal
i have a 33% chance of getting the placebo

sorry i want the real deal
if i dont after 18 months or so they will switch me over to the real deal
for a total of 4 1/2 years of infusions

i do realize since i have the apoe 4/apoe4 gene
i have an almost 40% chance of having significant side effects
mainly headaches if i get the higher dose of the
luckily few people have had to stop the study from these side effects

if it works
its all worth it

the real deal please

the organicgreen doctor

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