welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, March 2, 2018

alzheimers news-baceless

Image result for organicgreendoctor
in the amyloid theory of alzheimers disease
beta amyloid accumulates in the brain
this accumulation leads to brain cell death

many of the new drugs are aimed at
1 removing the amyloid thats accumulated in the brain
2 preventing it from being deposited
3 preventing it from being produced in the first place

the drug biogens aducanumab that i receive in my monthly infusions
at ucla if i am getting the real drug instead of the placebo
is an antibody that goes in and does 1 and 2
it removes the accumulated amyloid from the brain
it prevents it from being deposited in the brain by binding it
up before it can be stuck in the brain

as aside
i have now done 1 year of these infusions
in 6 months i will be switched to definitely getting
the real aducanumab for at least 2 more years
i am hoping that ive been on the real drug so that by
septermber 2018 i will have received 20 doses of the
real drug

if that is so my amyvid pet scan for the amyloid that was
in my brain 1 year ago should be all clear
fingers crossed

now there is a lot of research going on to block the
bace gene or beta secretase gene in the brain that
cleaves the beta amyloid to make the stuff that sticks in the brain

there is a tablet produced now that is taken regularly
is called a bace inhibitor
which means it blocks the gene
so the bad protein amyloid is not produced

by preventing the amyloid from being made it cant be
deposited in the brain

Image result for organicgreendoctor amyvid
studies using this bace inhibitor are ongoing now
in patients

who are prealzheimers
which means they have no memory issues but they have
positive scans like that above for the bad beta amyloid in the brain
if i had a scan 20 years ago it probably would have been positive
for the bad beta amyloid

who have mild cognitive impairment or early alzheimers

so by stopping or reducing the amyloid production in the brain
alzheimers disease would be slowed or stopped

recently researcheres were able to remove the bace gene
totally in rats with alzheimers disease
the rats memory improved back to normal
so there was no bad beta amyloid in the brain

so by removing this gene or inhibiting it with drugs
alzheimers disease could be prevented or slowed down

maybe in the future
folks will take a bace inhibitor pill to prevent the
bad amyloid from being produced
add a drug like aducanumab that i am on
to remove any beta amyloid that was produced or deposited
you could treat
if we are lucky
cure alzheimers disease

lets hope we are this close

the organicgreen doctor

No comments:

Post a Comment