alzheimers news-what does apoe4 mean for me and you

 ALZHEIMERS NEWS-WHAT DOES APOE4 MEAN FOR ME AND YOU
the apoe gene handles lipids think cholesterol in the body and in the brain
apoe stands for apolipoprotein e

we all have two of these genes
apoe2 the good one
it protects you from alzheimers
apoe3 is in the middle 
it protects you some from alzheimers
apoe4 puts you at risk for getting late onset alzheimers
the apoe4 gene is called the late onset alzheimers gene

if you are really lucky and have apoe2 and apoe2 you probably will not get alzheimers
1% have this one
if you have apoe4 and an apoe2 or an apoe3 then your risk of late onset alzheimers is increased 3 times
about 25% of yall have this one
if you have an apoe4 and an apoe4  then your risk of late onset alzheimers is increased 12 times
1% of us have this one

the good thing is that if you live a good healthy life doing things i will mention below then you can mostly counter the effects of being apoe4 or apoe4/apeo4
its important to start early in your life

i have the apoe4/apoe4 gene
i had an increased risk of 12 times
well i got alzheimers so i would say my risk must have been 100%

i inherited one apoe4 gene from my mother and one from my father
to get apoe4/apo4

this means my children are like 25% of you are they have at least single apoe4
if their mother has no apoe4 then they just have the single apoe4 gene

their kids if their kids mom has no apoe4 gene then they have a 25% chance of having apoe4 and a 75% chance they do not have it

so what if they did have one apoe4 gene
so what if they did have two apoe4 genes

will they get alzheimers
maybe

maybe not

its according to how they live their life starting when they are young
things i aggressively have being doing for 16 years

apoe4 does damage by mishandling lipids and cholesterol and lipids in the body and brain
it also seems to alter some biochemistry and metabolic pathways in the brain and alters the removal of the bad stuff beta amyloid from the brain

studies are being done to alter the apoe4 to convert it to apoe3 or apoe2 but those are in the early stages and could be years away before it reaches clinical trials

i suspect that eventually if you have apoe4 that there will be some type of treatment that will be done plus have you do all those healthy things below

so what do they do what do you do if you get it the apoe4 gene
at least 25% of you have it

you live a healthy life starting as soon as you are born

maintain a normal blood pressure normal cholesterol or lipid levels normal blood sugar
maintain a normal weight

eat a Mediterranean diet or mind diet
stay active mentally socially and physically

dont smoke
dont drink alcohol or limit alcohol
dont use addictive drugs
avoid certain drugs that can affect memory

get adequate sleep
if you have sleep abnormalities like sleep apnea get it evaluated and treated

control anxiety depression and stress

avoid head trauma as apoe4 individuals may be more susceptible to it

treat early on hearing loss or vision loss

if you chose to not do these healthy things and you have the apoe4 gene
then
you may get late onset alzheimers disease

if you do chose to do these healthy things and you have the apoe4 gene then you may not get alzheimers disease or a stroke or a heart attack or diabetes or certain cancers

having the apoe4 gene is not a good thing but it doesnt have to be a bad thing

so what did i do
i started all these things aggressively at 60 years old less so when i  turned 40

i wished i had done them years early like in my 30s or 40s

once i was diagnosed with mci or mild cognitive impairment due to alzheimers in 2010 i got aggressive with all of the  healthy things
i got put on aricept or donepezil which slows down symptoms and may prolong ones life some
i got treatment with intravenous antiamyloid antibodies called aduhelm which is now not available but its sister drug leqembi is available and another one called kisunla
there is even more treatments coming in the future

it is said that alzheimers is becoming a not untreatable disease

that is me talking and crying with the crowd at the walk to end alzheimers a couple of years ago
my wife and i have done the walk to end alzheimers for the last 16 years

join us or donate to our team or join and donate to a local team for your local walk to end alzheimers

the organicgreen doctor

organicgreendoctor: alzheimers news-what if you could get a vaccine ag...

organicgreendoctor: alzheimers news-what if you could get a vaccine ag...: ALZHEIMERS NEWS-WHAT IF YOU COULD GET A VACCINE AGAINST IT  fda when i was first diagnosed 16 years ago i read about the idea of an alzheime...

alzheimers news-what if you could get a vaccine against it

ALZHEIMERS NEWS-WHAT IF YOU COULD GET A VACCINE AGAINST IT 
fda

when i was first diagnosed 16 years ago i read about the idea of an alzheimers vaccine
you could get a shot on a regular basis to prevent you from getting alzheimers 
sort of like you do when you get your flu shot or covid shot

it was exciting to think of that happening
however
16 years later it still has not happened yet

when i first started talking and writing about alzheimers i wrote that the new vaccines were here but what they were was not vaccines but were infusions of antiamyloid antibodies  

one of the first to appear was my drug aduhelm or aducanumab
it was derived from older people who did not get alzheimers
so they made large quantities of this antibody these folks had in the lab
then
gave them to me and others in clinical trials

i identified this drug aducanumab later called aduhelm when it was in early clinical trials 15 years ago
there were other promising ones that that did not finish clinical trials
this happens to a lot of drugs

about 5 years after i discovered aducanumab i received 34 monthly infusions of aduhelm or aducanumab in a clinical trial i was in off and on for 6 years
once it was paused for covid and another time to look at the accumulated data
it took that long before it was available in a phase 3 trial
it would be 6 years before i finished my treatement
thats 12 years from when i first read  an article on the drug and tracked down the clinical trial

my initial amyloid pet scan in 2016 was positive for amyloid plaque
my final amyloid pet scans 2 years ago in 2024 was negative for amyloid plaque
a 2 year follow up amyloid pet scan done this year 2026 was still negative for amyloid plaque

hopefully removing this amyloid plaque will slow down the disease some
estimates are is a 30% slow down
not prefect but i will take it

this treatment took me 6 years of over 50 trips of 9 hours to first the university of texas southwestern in dallas and later ucla

my drug aduhelm was taken off the market since its sister drug leqembi worked better and now leqembi can be given as injections at home instead of going to an infusion center

another drug called kisunla works similar and is available

if i need retreatment i plan on take leqembi injections at home

what if
what if 

you could just take an alzheimers vaccine that removes the amyloid and if it works would slow down the disease by removing amyloid from the brain

you could get one every year

that time may soon now be here

a company called neurovax has developed a vaccine called av-19558r

it was given to 16 patients 4 were placebos
the 12 that got the real drug developed antibodies against amyloid
the study did not look at did it remove the amyloid

now they have a phase 1 study of 160 participants with amyloid in the brain and they will be given av-19558r and followed longer to see if it removes the amyloid

if that works then on to phase 2 then phase 3
if it really works it might be available in 5-10 years

just think in a few years if you have amyloid plaques without memory loss you might be able to get a vaccine that will remove the amyloid plaques from the brain like aduhelm did for me

without doing all those lengthy infusion visits

Just a shot in the arm like a flu shot
or
it might not work at all 

we are getting closer
when looking at early research you never know where it will lead
the potential is there for this one for sure

Here is the link to an article on the neurovax vaccine

now we wait

if you are in the alzheimers world i suggest you follow beingpatient.com to keep up with what is happening in the alzheimers world

i daily read articles on alzheimers and follow beingpatient.com looking for the next treatment that may help

yes
i would take this vaccine in a study if i could

that is me talking and crying with the crowd at the walk to end alzheimers a couple of years ago
my wife and i have done the walk to end alzheimers for the last 16 years

join us or donate to our team or join and donate to a local team for your local walk to end alzheimers

the organicgreen doctor