welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, July 19, 2024

organicgreendoctor: alzheimers news-new drug kisunia for early alzheimers

organicgreendoctor: alzheimers news-new drug kisunia for early alzheimers: ALZHEIMERS NEWS-NEW DRUG KISUNIA FOR EARLY ALZHEIMERS there are now 3 drugs approved by the fda to treat early alzheimers or mid cognitive i...

alzheimers news-new drug kisunia for early alzheimers


there are now 3 drugs approved by the fda to treat early alzheimers or mid cognitive impairment due to alzheimers

these drugs do not work in the genetic early onset alzheimers patients like those with the presenilin gene
they only work in later onset alzheimers like i have

in the theory of alzheimers amyloid plaque builds up and kills brain cells
later tau proteins unwind and form tau tangles in the nerve cells and kills brain cells
later inflammation occurs in the brain and kills brain cells

if you could remove the amyloid plaques or keep them from forming then maybe you could slow down the disease

antiamyloid monoclonal antibodies either prevent the amyloid plaques to form or remove them if they form

the 3 monoclonal antibodies against amyloid plaques are
aduhelm or aducanumab
leqembi or lecanemab
kisunia or donanemab

my drug i took for 34 months is aduhelm
they did a rocky introduction and tried to get approved before all the studies were done
even though it was approved for use it was eventually taken off the market since its sister drug made and marketed by the same company worked better
its sister drug is leqembi
aduhelm worked it just takes longer
after my 34 months of infusions my amyloid plaque is gone on my amyloid scan

leqembi works better and a little faster than aduhelm and with fewer side effects
although the side effects still happen ie aria or brain edema or brain bleeds
treatment is probably only for about 18 months
its given every 2 weeks as an infusion

the newest drug kisunia works faster and stronger
its given every month for about 12 months or until the amyloid pet scan is negative then its stopped
retreatment may be done when the amyloid reaccumulates
this could be 2-5+ years

kisunia seems to have more aria or edema or brain bleeds but it also seems to work better

those at worse risk for the bleeds are those like me with the homozygous apoe4 apoe4 gene
giving these drug in patients like me have to be done with great caution

how well do they work
at best expect a mid 20-mid 30% slowing in cognitive decline
im not sure what they means in regards to what you see in your affected love ones
the earlier the drug is started the better the results will be
i probably am one of the earliest to have been put on these drugs
i should get better results

all 3 of these drugs are being evaluated in patients who are have no symptoms
yes no symptoms
but they have positive amyloid plaques in their brain
they have normal memory tests
those studies should be reported in 3-5 years

these prealzheimers patients will probably get better results long term
eg for me i should have been treated in my 50s

so which would i chose
i am apoe4 apoe4 positive so i would have to be careful taking the kisunia since they use a more aggressive treatment
but they are given once a month

leqembi is given twice a month so thats a problem
they are working on giving it as an at home shot so you wont have to go to an infusion center
a real pain sometimes
they also are looking to change to monthly treatments at least for maintenance treatment

both of these leqembi and kisunia will need to be given intermittently to keep the amyloid from reaccumulating

I would probably chose leqembi because i am apoe4 apoe4

you do your treatments
when the amyloid reaccumulates then you retreat at a maintenance dose

you will need tau tangles treated
drugs are now in clinical trials for that

a new drug is in trials that treats inflammation
i expect those to be available in 5 years
hopefully not too late for me

so would i 
yes i would take an antiamyloid drug now then when available take an inflammation drug and a tau drug
of course do all those healthy things should be doing all our lives
these healthy things have better long term results than any drug

the organicgreen doctor

Wednesday, July 17, 2024

organicgreendoctor: my story revisited #207-i still need my sleep

organicgreendoctor: my story revisited #207-i still need my sleep: MY STORY REVISITED #207-I STILL NEED MY SLEEP sleep is when the garbage can guys in your brain called microphages go into the brain and clea...