welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, June 7, 2019

alzheimers news-a moral obligation

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thats what one researcher wrote about pfizer one of the big pharma companies
they had a moral obligation to investigate this further

i will link an article that goes into more detail on all of this
here is my explanation and thoughts as i see all this

alzheimers is an inflammatory disease where there is inflammation in the brain probably from the amyloid and tau thats deposited in the brain
the body then attacks all this with inflammation that destroys brain tissue

think of a splinter stuck in the finger and left in place
the puncture wound gets sore red swollen and gets pus in it
thats the bodys inflammatory reaction to injury
it tries to fix things when injury occurs
in doing so it does damage the surrounding tissues
so it is in the brain with inflammation
it destroys tissue ie brain tissue
for those of us with the disease we lose memory first then worse things happen over time

many scientists think that if you treat this inflammatory reaction in the brain or elsewhere in the body that you might be able to prevent or slow down alzheimers disease

common areas that may be involved is the gut where the inflammatory reaction goes on
eg ulcerative colitis or crohns disase or maybe celiac disease
another area they are looking at is the inflammation that can come from gum disease

rheumatoid arthritis the inflammatory disease thats treated with enbrel also is another site
rheumatoid arthritis patients have a higher incidence of alzheimers disease

this inflammation outside the brain gets the inflammatory response to be carried into the brain

enter pfizer
big pharma
they decided to shut down their alzheimers and parkinsons research branch since all their drugs they studied didnt really help
including one similar to the aducanumab drug that i was on for almost 3 years and that just stopped its international study

enbrel is a drug that attacks inflammation in the body
its been around since the mid to late 1990s
its mainly used against rheumatoid arthritis and most recently psoriasis

it the enbrel is due to go off patent since its had its 20 year run before other companies can start making it in the generic form

back in 2015 after looking at thousands of insurance claims it was noted by pfizer and other researchers that folks on enbrel didnt seem to get alzheimers or my disease mild cognitive impairment as often as those who werent on it
it was a definite blip that showed up on the data when they analyzed it

it would seem to me and it seems after all the reaction to this story that we all agree that this warranted more evaluation
i can tell you from someone who knows whats coming in my life and my familys life in the next probably 10 years that i would be the first in line if they wanted someone to study this drug further

side effects are not an issue
if you have been through alzheimers disease with a family member i think you would probably agree
that final stage is much much worse than any side effect you or they could have

so here is what my cynical self thinks

the drug  was going off patent
if they spent the $80 million to study the drug to see if it really really had an effect that if it did by the time the study was finished the drug would be off patent

any effort to study this was shut down

one excuse is thats the enbrel molecule is too big to go through the blood brain barrier so they say  that the drug wouldnt work since it couldnt get into the brain

i know and others know who do research and those who write about alzheimers know that its very likely that treating inflammation elsewhere in the body may slow down this disease
its not definitely proven yet but i think it will be

you can prevent dental inflammation by flossing regularly and brushing regularly and having regular dental cleanings and dental care
proven no but most likely to contribute to the disease

you can eat a diet like the mind diet that may help prevent gut inflammation
some folks eat a lot of fermented foods
some eat a gluten free diet
many take probiotics
proven no but most likely the gut inflammation contributes to the disease

so what we have here is a big pharma that hid this from alzheimers researchers
the studies that need to be done like those on the above inflammatory sites the teeth and the gut and on enbrel probably wont be done since the studies are expensive
it takes millions of dollars to do this research

this company if they did the study and it helped would have been competing with other generic makers of enbrel for the business
they would have spent all the money with little financial rewards
they have to answer to the stockholders to show a profit

the only other source to do these big studies is the federal government
like the national institutes of health and the alzheimers association and other non profit groups
which dont have the money to pay for it

we are left with a nauseated feeling in our stomach and a bitter taste in our mouth as we look at this and think would it really help
is there a moral obligation to do this research

like one well known alzheimers researcher said even if it doesnt end up helping just the research thats done may help further the overall alzheimers research

its like in politics and in life
sometimes you just have to do the right thing
pfizer didnt do that

maybe its the times

when asked what do you feel about this
i said
i feel real nauseated

the organicgreen doctor

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