welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, June 5, 2020

alzheimers news-this leukemia pill may help

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in the theory of how alzheimers develops in the brain there is first an accumulation of beta amyloid that causes amyloid plaques that kill brain cells
inside the brain cells there are tau proteins
these tau proteins get damaged and unwind to form tau tangles which also cause brain cell destruction
where the tau tangles start showing up is usually what part of the brain shows symptoms

you can measure beta amyloid in the brain with an amyloid pet scan and in the spinal fluid
you can measure the tau levels also in the spinal fluid
now there is a new tau pet scan that just got approved that also measures tau levels in the brain

the thinking is if you can remove the amyloid and later the tau you can slow down the disease
the drug aducanumab i was on and am still waiting for the study to restart again removes the amyloid from the brain and maybe affects the tau levels

so remove amyloid and tau especially early on you might be able to slow the disease down

nilotinib or brand name tasigna
its a drug a pill thats given for chronic myeloid leukemia or cml
its already fda approved for this use
ready to be used in alzheimers
once of course the research is done

here is a link to an article and here to the research article on using nilotinib in mild to moderate alzheimers patients to lower the amyloid and the tau levels in the brain

its given for cml at 600 mg twice a day
the biggest side effect at that high dose is it affects dopamine and can cause mood swings
also at the higher levels it can prolong the qt length on the ekg causing arrhythmias
at lower doses it doesn't seem to do either of those very often

this study was a phase 2 single center randomized double blind placebo controlled study for 12 months
in the treatment group or non placebo group they got 150 mg for 27 weeks then changed to 600 mg

they think nilotinib may work by going into the brain through the blood brain barrier to stimulate the garbage cells in the brain to remove the amyloid and amyloid plaques and the tau tangles

the question will be if you do that will the disease get slowed down
that remains to be seen and hopefully answered in a larger phase 3 study

what they found
the amyloid plaques were reduced on the pet scans for amyloid in the brain
the amyloid levels in the spinal fluid were changed
the tau levels in the spinal fluid were changed also
there were little side effects noted
it did what they wanted it to do

it seems the lower dose of 150 mg may be the dose to use

whats next
a phase 3 study giving nilotinib to a much larger group
this study will answer if it helps
since its already fda approved then it could be easily used to treat early alzheimers

this drug has been used for awhile for cml and has been generally well tolerated

the phase 3 study confirms its working in alzheimers disease

this drug is about $15,000 a year at discounted prices but is covered some by insurances usually
my drug is expected to be between $50,000+ a year if its approved

the organicgreen doctor

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