new alzheimers vaccines

ALZHEIMERS NEWS-NEW ALZHEIMERS VACCINES

when i first heard about the new drugs that were antibodies against amyloid plaques i called them alzheimers vaccines

actually they were monoclonal antibodies that were manufactured in the lab against the amyloid plaques
thousands and thousands of these antibodies were given with an infusion

my drug aduhelm was derived form a collection of antibodies obtained from older folks who did not get alzheimers disease

aduhelm was a collection of these antibodies as is the new drugs leqembi and kisunia
but
they are not vaccines

vaccines are like mmr flu covid rsv tetanus dpt  polio to name a few

these are antigens given in the shot that stimulates the body to produce our own antibodies against a particular virus or bacteria

several years ago they developed an alzheimers vaccine against alzheimers using antigens that were the whole amyloid protein so the body made antibodies against the amyloid protein
the problem was the body uses the amyloid protein for good things too
the vaccine worked but it also made people sick real sick like brain swelling sick
so
it was discontinued

now
researchers figured out if they broke the amyloid protein into parts and used the parts implicated in alzheimers that the body would make only antibodies against those parts and it seemed to work without all the bad side effects

in the theory of the development of alzheimers amyloid plaques form and kills brain cells
later
tau proteins began to unravel and form tau tangles which kills more brain cells
later
inflammation occurs that makes it worse

now
there are vaccines against the amyloid plaques
there are vaccines against the tau tangles

when do you give these
researchers are lookiing at folks who are early in the disease with minimal symptoms or even those who have no symptoms yet

maybe
even giving them long before symptoms start

the thinking would be to identify those with positive biomarkers for alzheimers disease
yes those will be available soon like within 5 years at your doctors office
if yours are positive then you could be given an alzheimers vaccine against amyloid plaques or tau tangles
maybe preventing you from getting alzheimers

these clinical trials are ongoing now 
some are in the phase 3 stage
which means they could be available for the public in 5 years

if they work

would i take one of these if i was 40 or 50 and had positive amyloid biomarkers and or positive tau tangle markers
the answer is with no hesitancy
yes
you betcha

pending of course no unusual or bad side effect that shows up in these studies

remember one thing that came out of the clinical trials for aduhelm leqembi and kisunia was the small incidence of brain bleeds called aria 
some were fatal

most at risk were those who carry like me the apoe4/apo4 gene

it wouldnt have and it didnt prevent me from taking my 34 monthly infusions of aduhelm

luckily i did  not have any aria

here is a nice article on this in being patient

count me in