welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, March 27, 2015

alzheimers news-a game changer

first a few years ago i had an infant that i cared for that
developed seizures that were difficult to control
imagine having a baby having seizures you cant stop
they tried the usual meds
but they didnt work

Image result for levetiracetam 250 mg
a new medicine called keppra had just came on the market
since she was at childrens hospital they used it on her
it worked
after 2 years she tapered off it and has been seizure free since

this drug is now available in its generic form levetiracetam
in a study recently low doses were given of 62.5 mg to 125 mgm
twice a day
for seizure control 500 mgm twice a day is given up to
3000 mgm a day

this low dose was given to patients with
mild cognitive impairment amnestic type
thats my official diagnosis

the results were that their memory tests improved significantly
that patients with this diagnosis could have their memory
improved with this generic drug

bring it on is what i say

the game changer

inside the brain of someone that has alzheimers disease
even years before symptoms start
the bad stuff beta amyloid starts to accumulate

it is easily seen on a amyvid pet scan like this one
thats all the red stuff on the scans

several companies have developed new drugs
that i call the alzheimers vaccines
using antibodies to capture that bad stuff beta amyloid
in the brain and removing it

there are several large studies going on right now
in patients with positive scans with no symptoms
in patients with the dominant gene
in patients with mild cognitive impairment
in patients with mild alzheimers and moderate alzheimers

a company called biogen has one called aducanumab
it was given to 166 patients in a phase 1 study who had early
alzheimers disease and positive amyloid scans

they were followed up to 41/2 years
the higher the dose used the better the results

the placebo group who received fake stuff
had no decrease in the amyloid on the scans or improvement
on memory tests

the treatment groups especially the higher dose
showed a decrease in the beta amyloid in the brain that was
seen on the brain scans
that correlated with
an improvement in the memory tests

this was significant

what this means is
the alzheimers vaccine seems to work by removing the
bad stuff amyloid
thats seen on scans
the patients memory improves noticeably at the same time

this is what we want right

the company is skipping phase 2 studies and are going
straight to phase 3 studies on a much larger group of folks

phase 3 is the stage that really proves if it works or not
then if it does it gets fda approval for
treatment of alzheimers disease

if it works
these drugs will be given to folks at high risk for alzheimers
years before the disease shows up as symptoms
slowing down the disease process
if we are lucky
preventing it

this folks is a real
game changer

i will be first in line for this one for sure

the organicgreen doctor

No comments:

Post a Comment