alzheimers news-it works on mice

ALZHEIMERS NEWS-IT WORKS ON MICE

yesterday i stood and answered questions from several folks
for about an hour and a half
this is the favorite presentation that i do
no slides
no handouts
no board to write on
just
me standing up there
telling briefly my story
getting the folks in the audience to ask me questions

i am surprised that folks arent aware more of
what causes alzheimers disease
what you can do to prevent or slow it down in your family
what exciting research is out there
that may bring us that treatment drug
finally

usually at these events there is usually a lot of wet eyes
as they talk or ask questions about alzheimers
and their loved ones

there just needs to be an education class
for folks when their family member gets diagnosed
you know like
when you get diagnosed with diabetes
you go to all those classes
explaining diabetes
esplaining what to eat how to exercise etc

well so should that be with alzheimers
an education class for alzheimers

maybe
ill start one

usually in the audience there is always at least one person
usually there are more
that is or is becoming an
isolated caregiver
looking sort of overwhelmed

there was one yesterday
she was linked up with caregiver groups
she was linked with the research center where i go
her husband probably qualifies for the study i am
trying to get into

yes
like my wife she says
education is a good thing

so we need it for alzheimers

i saw an article recently on this
can a cancer drug reverse parkinsons and dementia


there is a cancer drug that is used for leukemia
its approved by the fda already for it use

researchers at georgetown university gave it to mice who had alzheimers
yes mice get alzheimers
they the scientists put the alzheimers gene in the mices brains
it makes beta amyloid which accumulates
they all get alzheimers disease

the drug works by turning on the garbage cells in the brain
to clean up any rogue proteins in the brain
like beta amyloid thought to be the culprit in alzheimers disease

eg
the study i am trying to get in with the adu drug
aducanumab
was given to these mice
the beta amyloid a lot of it got cleared from the brain
the mice got better
next step
humans
it seemed to work in those first studied
next step
hopefully me

so these mice studies are important
the cancer drug is called
nilotinib

when given to parkinson patients they got better

now the georgetown researchers plan to give it to alzheimers patients
in a study

if it really works its already available legally
all will need to happen is to have a doctor order it

maybe hopefully it will work
im game

the organicgreen doctor

alzheimers news-is this the one

ALZHEIMERS NEWS-IS THIS THE ONE



there has been an observation over the years
that folks who get chemotherapy for cancer
seemed to not get alzheimers as often

an article
here is the link
describes the approval of a phase 2 study
for a
no not a new drug
a drug already approved by the fda
for use in certain leukemias


its called nilotinib
brand name tasigna

what this means is that its already on the market
really any doctor could order it off label
if they wanted to

an example of an off label use of a medicine
was
albuterol brand ventolin and proventil

originally it was not approved for use in kids under 12
in my practice at one time
most of my use of albuterol
was in that age group
so
i was using it off label
ie
 not approved by the fda for that age group

so
this drug is just sitting that with this potential to work
it has already been used in lewey body dementia
think robin williams
and in parkinsons disease
with good success

so in this study phase 2 it will be used in folks
with mild to moderate alzheimers

they will be using lower doses of the nilotinib

how it works is it goes through the blood brain barrier
to stimulate the garbage cleaner cells to
eat up the bad beta amyloid and the tau tangles that
have accumulated in the brain
these two are the hallmark of alzheimers disease

i am afraid that like a lot of alzheimers studies
they are treating the wrong group of folks
they used stuff later in the disease before and it didnt work well
it really needs to be used in folks with normal memory
or with
folks with early symptoms
who could take this medicine to prevent damage from
occurring in the first place

like me for example
eg
i had short term memory loss diagnosed as
early mild cognitive impairment amnestic type
which means this could be early alzheimers disease

i take aricept (donepezil) and am aggressively taking care of
my health
doing all the healthy things i can to slow it down

i have the apoe 4 double gene putting me at high risk
for having alzheimers disease

my level of bad beta amyloid and tau in the spinal fluid
were near alzheimers disease levels five years ago

i am about to get the amyvid pet brain scan for the bad
beta amyloid
if its there i most likely have alzheimers disease

so i am a prime candidate if its positive for a treatment
like this one
i still have a lot of brain left to protect
lock me in to where i am now
i would be quite happy

so this drug is a chemo drug
with a list of side effects
like
nausea vomiting diarrhea constipation headache fatigue
low blood count muscle and joint pain uri sx etc

heck
ive had a lot of these just from taking my aricept (donepezil)
and
from a chronic problem with iritis
and
from just plan old osteoarthritis and an old ruptured disk

i think i could handle these side effects if i were to take
this pill

especially when you consider the side effects of
alzheimers disease
like
certain death from it
losing short term memory
eventually losing all memory
not knowing your wife your kids your grandkids
mumbling gibberish
having to be fed
drooling
having to be diapered
having problems walking
getting lost
becoming eventually bedridden
changing your personality sometimes for the worse

sorry
ill take this chemo drug any day
no side effects can match what would be in store
for myself
and
my family

bring it on i say
i am ready now


we will be walking in another
alzheimers texas walk
at
camp mabry in austin texas
at
the travis county alzheiemers texas walk
on
next saturday october 8, 2016
for the
austin regional clinic team

donate and or join us
to help
in the fight against this disease

we are getting closer to a treatment or cure

the organicgreen doctor