welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, September 30, 2016

alzheimers news-is this the one


Alzheimer's Texas

there has been an observation over the years
that folks who get chemotherapy for cancer
seemed to not get alzheimers as often

an article
here is the link
describes the approval of a phase 2 study
for a
no not a new drug
a drug already approved by the fda
for use in certain leukemias

Image result for tasigna
its called nilotinib
brand name tasigna

what this means is that its already on the market
really any doctor could order it off label
if they wanted to

an example of an off label use of a medicine
albuterol brand ventolin and proventil

originally it was not approved for use in kids under 12
in my practice at one time
most of my use of albuterol
was in that age group
i was using it off label
 not approved by the fda for that age group

this drug is just sitting that with this potential to work
it has already been used in lewey body dementia
think robin williams
and in parkinsons disease
with good success

so in this study phase 2 it will be used in folks
with mild to moderate alzheimers

they will be using lower doses of the nilotinib

how it works is it goes through the blood brain barrier
to stimulate the garbage cleaner cells to
eat up the bad beta amyloid and the tau tangles that
have accumulated in the brain
these two are the hallmark of alzheimers disease

i am afraid that like a lot of alzheimers studies
they are treating the wrong group of folks
they used stuff later in the disease before and it didnt work well
it really needs to be used in folks with normal memory
or with
folks with early symptoms
who could take this medicine to prevent damage from
occurring in the first place

like me for example
i had short term memory loss diagnosed as
early mild cognitive impairment amnestic type
which means this could be early alzheimers disease

i take aricept (donepezil) and am aggressively taking care of
my health
doing all the healthy things i can to slow it down

i have the apoe 4 double gene putting me at high risk
for having alzheimers disease

my level of bad beta amyloid and tau in the spinal fluid
were near alzheimers disease levels five years ago

i am about to get the amyvid pet brain scan for the bad
beta amyloid
if its there i most likely have alzheimers disease

so i am a prime candidate if its positive for a treatment
like this one
i still have a lot of brain left to protect
lock me in to where i am now
i would be quite happy

so this drug is a chemo drug
with a list of side effects
nausea vomiting diarrhea constipation headache fatigue
low blood count muscle and joint pain uri sx etc

ive had a lot of these just from taking my aricept (donepezil)
from a chronic problem with iritis
from just plan old osteoarthritis and an old ruptured disk

i think i could handle these side effects if i were to take
this pill

especially when you consider the side effects of
alzheimers disease
certain death from it
losing short term memory
eventually losing all memory
not knowing your wife your kids your grandkids
mumbling gibberish
having to be fed
having to be diapered
having problems walking
getting lost
becoming eventually bedridden
changing your personality sometimes for the worse

ill take this chemo drug any day
no side effects can match what would be in store
for myself
my family

bring it on i say
i am ready now

we will be walking in another
alzheimers texas walk
camp mabry in austin texas
the travis county alzheiemers texas walk
next saturday october 8, 2016
for the
austin regional clinic team

donate and or join us
to help
in the fight against this disease

we are getting closer to a treatment or cure

the organicgreen doctor

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