welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, December 16, 2022

alzheimers news-aricept or donepezil vs lecanemab


i have been on aricept or donepezil for 12 years
aricept or donepezil blocks an enzyme so acetylcholine will accumulate in brain nerve endings so they will work better
this makes damaged brain nerve cells work longer
thus the memory loss is slowed but not the disease

i take monthly infusions of aduhelm or aducanumab at ucla in a clinical trial
i have had 24 of these 

my drug aduhelm is made by biogen and eisai 
it is a monoclonal antibody that binds to and removes amyloid from the brain
amyloid accumulates in alzheimers disease

lecanemab is a monoclonal antibody that is made by biogen and eisai
it is a monoclonal antibody that works similar to aduhelm

aduhelm may reduce memory decline by 22%
the results of my study will be out in about 2 years
it will confirm if this is true

lecanemab reduces memory decline by 27%

aduhelm is approved for use by the fda but medicare and insurances wont pay for it
its due to the way it was rushed through the system to get it approved
the research had not been all finalized but should be in 2 years
it wasnt handled right
few doctors are ordering its use

lecanemab is doing it right 
note the same folks made it and are promoting it
this time they are doing things right

they both have the side effects of aria or microbleeds
aduhelm has a higher incidence than lecanemab

most of us with this diagnosis dont worry about these side effects
what would you do if you had terminal cancer and got a chance to take a drug that might slow it down to give you more time with your loved ones
i like many alzheimers patients accept these risks

my guess is lecanemab will be approved and will be the one thats used instead of aduhelm

dr daniel gibbs writes a blog called a tatoo on my brain
this week he wrote about a friend who writes an alzheimers blog
his friend is a pediatric oncologist and is a caregiver for his wife with alzheimers

his friend wrote this blog linked here about asking was aricept as good as lecanemab for slowing down symptoms
probably i said to myself

i said to myself
what if you took both of them together

would the memory decline be slowed even more

man i sure hope so
ive been on aricept or donepezil for 12 years
ive been on aduhelm for 2 years and will be on it for another 2 years

there are a lot of people in these studies using either aduhelm or lecanemab who are also on aricept or donepezil 
it would be interesting to compare them to those folks who werent on aricept but were on lecanemab and those who are on placebo and on aricept or on nothing
that might answer the question

this is a graph i posted on this blog i wrote recently
i wrote i was glad i started aricept or donepezil 12 years ago
the top line is folks on aricept
the bottom line is folks not on aricept
their mmse memory tests were done over a 12 year time period
those on aricept had much better memory tests than those not on aricept
those on aricept also lived longer also


 this graph from this article linked here is graph of memory tests done on patients on lecanemab vs patients not on lecanemab ie placebo
if you look at the 2 graphs the aricept one and the lecanemab one they look similar

i suggest
that they do one where they are on both meds and lets see what it would look like
they have the data theyve collected already 

my thoughts
it probably helps to me on both
im glad im on both ie aricept or donepezil and aduhelm

this may be the new treatment that newly diagnosed alzheimers patients who have not progressed too far will be offered

if it was me i would do it

wait i am doing it already

the organicgreen doctor

follow me on twitter
follow my blog facebook page

No comments:

Post a Comment