welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, November 19, 2021

alzheimers news-nasal alzheimers vaccine may slow down the disease


several years ago as i was ending the five year adni 2 or alzheimers disease neuroimaging initiative 2 study there was a study about to start that i almost entered
im glad i didnt since it might have delayed or prevented me from being in the biogen aducanumab now aduhelm study
the aduhelm or aducanumab was approved for use in mci and early alzheimers disease by the fda

in the nasal study i was looking at they were going to use nasal insulin that was sprayed into the nose
the insulin traveled up the olfactory nerve or as i call it the smeller nerve to the brain
there the insulin forced glucose into the brain cells making them work better
in initial studies it seemed to help
they had trouble getting the insulin formulated and had trouble getting an adequate delivery system for the insulin
i dont know if the study ever got done

im just glad i didnt get nto the study

now almost 8 years later another nasal spray is being studied 
they are about to open a clinical trial on folks who have early alzheimers
they will be given the drug twice over a period of time then the patients will be studied to see if this medication helps slow down memory loss or if it improves the patients memory

in the study a drug called protollin an immune modulator is administered via a nasal spray
the drug stimulates white cells in the lymph nodes on the sides and back of the neck to
enter the brain to remove amyloid plaque 
basically it uses the immune system to treat alzheimers disease

this protein protollin will be used in this phase 1 study on a limited number of folks to check for its efficacy and potential side effects

here is an article on it

if it is safe and seems to be effective then it would move to phase 2 studies

the process from now to when it would be available if it works may be 5-10 years
it warrants keeping an eye on this study

for me
aduhelm or aducanumab is the last drug that may help that i will be able to take most likely 
by the time some of the better drugs come available ie get fda approval i will probably be too advanced by then with my disease

since i am on aduhelm or aducanumab i very unlikely would qualify for any future clinical trial treatment programs

i knew that when i continued the aduhelm or aducanumab study 
i didnt want to lose any time being not treated
i went for the aduhelm or aducanumab treatment study

eg in about 6 months from now after having received a year of aduhelm or aducanumab treatment i will have an amyloid pet scan to measure the amyloid levels in my brain
there may not be any measurable amyloid on my amyvid pet scan

this is one of the tests thats used in clinical trials to measure the effectiveness of treatment

if its negative to begin with then i wouldnt get into the new studies

so if you are in the alzheimers world keep an eye on the clinical trials that are ongoing
there will be new blood tests available soon to tell you if you have it
there are several promising drugs being studied that may work much better than my drug aduhelm or aducanumab

like eg
this protollin immune modulator to be given as a nasal spray

it probably wont have worse side effects than those covid shots or flu shots

the organicgreen doctor

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