welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, October 27, 2023

alzheimers news-wish i could do this one


the study i am in was presented at the clinical trials on alzheimers disease in boston this week
i have not been able to find the results yet
i do have an appointment next week art ucla where i see the research neurologist who was at the conference and we will get a report on what our study showed from her

my drug aduhelm removes amyloid plaque slower than the leqembi drug does
the question is after 3 years of infusions is the plaques all gone ie does it work as well as leqembi does
i think the results will show it does

leqembi reported out its study where it was given as a shot ie subcutaneous injections every week
its results show taking it as a shot works as well as getting bimonthly infusions
what this means its you can give it to yourself at home each week
they are applying for fda approval in march to do just that

the big hassle of getting infusions is the trip to the infusion center and waiting on the infusion to be readied by the pharmacy then getting the infusion over an hour
our trip from the time we leave our house to the time we return is about 7-9 hours depending on traffic

in the future if i were to receive leqembi i could get it at home
probably a 10 minute event

my guess is my drug aduhelm even though it probably will work will fall by the way side and leqembi and the soon to be released donanemab will dominate the alzheimers treatment market

this week a new study at ucsf university of california at san francisco caught my eye

if i could qualify i would enter this study
my enigma is that ive had my amyloid plaque removed by aduhelm and until it returns over the next 5-10 years i probably wont qualify for any studies

tau tangles in the brain are lowered somewhat by the aduhelm and leqembi and probably donanemab but not significantly enough to probably make a difference

in the ucsf study they will be giving leqembi to remove the amyloid plaques but then also they will be giving two new anti tau drugs that will remove the tau tangles
treating 2 of the 3 things that occurs in alzheimers thats does all the damage
amyloid plaques and tau tangles

the only thing left is the inflammation 
new drugs are being studied now to do treat the inflammation 

all 3 of these destroy brain cells

we are getting closer to treating this disease with drugs that will significantly slow it down

anti amyloid drugs like aduhelm leqembi or donanemab are here now
anti tau drugs are in the final studies and will eventually be available
anti inflammation drugs are in early studies

for me
i will try to get an anti tau drug as soon as its available 
i probably will not be able to get in a clinical trial since i took aduhelm
when the antiinflammation drugs are available ill take those

for many of you younger than i am 
you will need to be diagnosed early 
maybe even before you have symptoms
you will be able to get these 3 classes of drugs to slow down or stop alzheimers

we are getting closer to someone getting that white alzheimers flower for the first survivor of alzheimers
who knows
that could be me

the organicgreen doctor

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