welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Tuesday, June 8, 2021

alzheimers news-the fda did the right thing


aducanumab after getting fda approval has its new brand name 
it is 
aduhelm (aducanumab)

yesterday the fda did the right thing by approving it for use in early alzheimers since it shows that it may decrease cognitive decline in these patients by 22%

in the alzheimers world we will take 22%

the fda did the right thing like i thought they would 
they gave it the accelerated approval pathway
basically used for drugs for untreatable diseases that may slow down the disease
not cure them but slow them down

then biogen will have to do a phase 4 study for probably 5 years to see how well it really works
by that time thousands will have gotten the drug
by then 
we will know how well it works

if its doesnt work then it may be removed from the market

in 5 years there are drugs that will be here that work similarly to aduhelm that will probably work much better eg one may show 30%+ improvement in cognitive decline 
each subsequent new drug will probably work much better than the last one

thats usually how drug treatment goes
like cholesterol like high blood pressure like diabetes etc

aduhelm is the inflection point for alzheimers treatment 
it will be known as the one that started the alzheimers treatment movement that is on the way in the future

ive read all the negative reviews
i have elected now to turn them off
us in the alzheimers world will mostly do the same thing

the decision is made
now lets see how well it works

the cost will be around $4000+ a month or around $50,000+ a year
thats the cost of treatment for things like connective tissue diseases like rheumatoid arthirits or lupus or ulcerative colitis etc or cancer

you can only imagine the rush there will be for folks to gain access to this drug
there may not be enough neurologists enough infusion centers enough mri scanners to keep up with the demand

the side effects mentioned in the news and in the products package has not been a worry for those of us involved in the studies of aduhelm
allergic reactions
brain swelling and microbleeds

if you think about it this amyloid plaques has been in the brain for years 
now the body will be removing them from the brain 
the body and the brain is not going to like that happening
i think of it like a wound with a scab on it
you peel the scab off 
the wound bleeds some then it heals
so it seems thats what may happen when the amyloid plaques are removed
yes it needs monitoring

the allergic reaction and the brain swelling and the microbleeds were risks and side effects that were explained to you
i signed several documents with those risks well described in them
i signed the documents without the blink of an eye
i never thought twice about it
my guess thats what those about to get these infusions of aduhelm will do also
not blink at all

remember what the choice is if you do nothing
its not good its fatal

mris of the brain will be done to monitor for these changes
all mine have been normal
those with the apoe 4 apoe4 gene like me are at higher risk

this drug aduhelm
give us in the alzheimers world one thing
some hope

you can see it and feel it as you read the alzheimers worlds social media postings

i can close my eyes and feel the vibes

it is important for folks to keep this drug in its proper perspective
it is not a cure
it is not for all azheimers patients
it is not for folks whose alzheimers has progressed too far
it is for folks with mild cognitive impairment due to alzheimers disease and those with early alzheimers
it has to be given early in the disease to be effective
in fact
the stage you are in will determine if you meet the criteria to get the drug

lucky for me i fit that criteria

also lucky for me i have had 7 infusions of this drug and am being reevaluated for inclusion in a study for at least 2 years to get aduhelm in monthly infusions

one question i have not seen is how long one has to take this drug 
since i know that the process that deposits the amyloid in the brain will continue
its like a boat with a hole in it
you may have to continuously remove all the water from the boat to keep it from sinking

for those who dont know i was in the biogen aducanumab study for about 25 weeks 
i got 18 months of placebo and 7 months of aduhelm
it was suppose to be continued a year ago but it was delayed by the pandemic
the study i was in at ucla is being reactivated
if approved i may restart the infusions this summer

the fda did the right thing

hope we will take every time

the organicgreen doctor

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