welcome to the organic green doctor blog

i am a family physician who was diagnosed with
early mild cognitive impairment(mci) amnestic type on december 21, 2010
this is a precursor to alzheimers disease
because of this diagnosis i have opted to stop practicing medicine
this blog will be about my journey with this disease
please feel free to follow me along this path
i will continue blogging on organic gardening, green living,
solar power, rainwater collection, and healthy living
i will blog on these plus other things noted to be interesting

Friday, January 28, 2022

alzheimers news-asthma drug studied for alzheimers treatment


alzheimers researchers are always looking at old medications that have been fda approved to see if they can be used as an alzheimers disease treatment

some researchers even use small microscopic worms that have the early onset alzheimers gene inserted in o the worms dna
they add a drug to the medium the worms are in in the lab and watch to see if it has an effect
its sort of a screening test for these old drugs and chemicals

there is an old drug that is being looked at to repurpose itself for use in alzheimers disease

the drug is singulair or montelukast that is used to treat the inflammation that occurs in asthma and allergies

im sure some of you with asthma may have been on this drug
its given as a pill

in the alzheimers theory
amyloid accumulates first and forms plaques
these plaques kill brain cells 
tau proteins in the nerve cells in the brain become unwound to form tau tangles
these tangles lead to nerve cell or brain cell death
the body sends in its inflammatory team to attack the inflammation in the brain
this also kills more brain cells

my drug aduhelm removes the amyloid plaque from the brain
other drugs in research some of which are tau protein monoclonal antibodies remove the tau tangles
there are drugs being developed to attack the inflammatory reaction in the brain

this is where they think singular or montelukast may help attack this inflammation in the brain

its now being studied in a phase 2 study linked here
they are using a version of singulair or montelukast that dissolves in the mouth
this gets the drug right into the blood stream since its absorbed in the mouth
it bypasses the liver since its not swallowed and doesnt go to the stomach 
so the liver doesnt break down the medicine 

using this sublingual or under the tongue form also allows the drug to be moved across the blood brain barrier to get to the area of inflammation in the brain

this study is a reactivated study that was paused due to the pandemic

it will be an interesting study to watch
i would take it if it shows it may help

if you live in canada or know someone there who wants to be in an alzheimers treatment study then here is the link to the clinical trial

maybe ill get me a prescription for my allergies

the organicgreen doctor

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